Kutane Lymphome
Translational Next Generation Sequencing
Cutaneous tumors
Pathogenesis of cutaneous vascular tumors (Pathology, Dermatology, Bioinformatics Unit CCC
Summary
The human skin can give rise to numerous benign, borderline and malignant tumors. One group investigated by us are neoplasia formed by blood vessels. In particular, we are interested in epithelioid hemangiomas, vascular malformations and angiosarcoma. Our goal is to find genetic aberrations that can be used as therapeutic targets but also to unravel the pathogenesis of these diseases.
Recent Publications
Wobser, M., K. Maurus, S. Roth, S. Appenzeller, G. Weyandt, M. Goebeler, A. Rosenwald and E. Geissinger (2017). "Myeloid differentiation primary response 88 mutations in a distinct type of cutaneous marginal-zone lymphoma with a nonclass-switched immunoglobulin M immunophenotype." Br J Dermatol 177(2): 564-566.
Frings, V. G., K. Roding, A. Strate, A. Rosenwald, S. Roth, H. Kneitz, M. Goebeler, E. Geissinger and M. Wobser (2018). "Paraproteinaemia in Primary Cutaneous Marginal Zone Lymphoma." Acta Derm Venereol 98(10): 956-962.
Maurus, K., S. Appenzeller, S. Roth, J. Kuper, S. Rost, S. Meierjohann, P. Arampatzi, M. Goebeler, A. Rosenwald, E. Geissinger and M. Wobser (2018). "Panel Sequencing Shows Recurrent Genetic FAS Alterations in Primary Cutaneous Marginal Zone Lymphoma." J Invest Dermatol 138(7): 1573-1581.
Wobser, M., A. Weber, A. Glunz, S. Tauch, K. Seitz, T. Butelmann, S. Hesbacher, M. Goebeler, R. Bartz, H. Kohlhof, D. Schrama and R. Houben (2019). "Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells." J Hematol Oncol 12(1): 30.
Maurus, K., S. Appenzeller, S. Roth, S. Brandlein, H. Kneitz, M. Goebeler, A. Rosenwald, E. Geissinger and M. Wobser (2020). "Recurrent Oncogenic JAK and STAT Alterations in Cutaneous CD30-Positive Lymphoproliferative Disorders." J Invest Dermatol 140(10): 2023-2031 e2021.
Frings, V. G., S. Roth, A. Rosenwald, M. Goebeler, E. Geissinger and M. Wobser (2021). "EBER in situ hybridization in subcutaneous aluminum granulomas/lymphoid hyperplasia: A diagnostic clue to differentiate injection-associated lymphoid hyperplasia from other forms of pseudolymphomas and cutaneous lymphomas." J Cutan Pathol 48(5): 625-631.
Wehkamp, U., C. Mitteldorf, S. Stendel, R. Stranzenbach, J. P. Nicolay, M. Wobser, M. Weichenthal, R. Schneiderbauer, C. D. Klemke, U. Hillen, W. Kempf and C. Assaf (2021). "Most rare subtypes of cutaneous lymphoma display variable CD30 expression: analysis of the German Cutaneous Lymphoma Network." Br J Dermatol 185(1): 228-230.
Wobser, M., S. Roth, S. Appenzeller, H. Kneitz, M. Goebeler, E. Geissinger, A. Rosenwald and K. Maurus (2021). "Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients." JID Innovations 1(3): 100034.
Wobser, M., S. Roth, S. Appenzeller, R. Houben, D. Schrama, M. Goebeler, E. Geissinger, A. Rosenwald and K. Maurus (2021). "Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation." Cancers (Basel) 13(21).
