Maligne Lymphome
Andreas Rosenwald: Pathogenesis of Malignant Lymphomas
Summary
Our group is interested in the pathogenesis of malignant lymphomas, including B- and T-cell Non-Hodgkin lymphomas, classic Hodgkin lymphoma and multiple myeloma. We use cytogenetic and molecular approaches as well as profiling and sequencing technologies to decipher pathogenetically relevant genetic and molecular changes of these tumors. This strategy might help to identify relevant targets for future therapeutic approaches.
Selcted Publications
Leich, E., Weissbach, S., Klein, H. U., Grieb, T., Pischimarov, J., Stuhmer, T., Chatterjee, M., Steinbrunn, T., Langer, C., Eilers, M., Knop, S., Einsele, H., Bargou, R., and Rosenwald, A. (2013) Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules. Blood Cancer J 3, e102.
Horn, H., Ziepert, M., Becher, C., Barth, T. F., Bernd, H. W., Feller, A. C., Klapper, W., Hummel, M., Stein, H., Hansmann, M. L., Schmelter, C., Moller, P., Cogliatti, S., Pfreundschuh, M., Schmitz, N., Trumper, L., Siebert, R., Loeffler, M., Rosenwald, A., and Ott, G. (2013) MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood 121, 2253-2263.
Richter, J., Schlesner, M., Hoffmann, S., Kreuz, M., Leich, E., Burkhardt, B., Rosolowski, M., Ammerpohl, O., Wagener, R., Bernhart, S. H., Lenze, D., Szczepanowski, M., Paulsen, M., Lipinski, S., Russell, R. B., Adam-Klages, S., Apic, G., Claviez, A., Hasenclever, D., Hovestadt, V., Hornig, N., Korbel, J. O., Kube, D., Langenberger, D., Lawerenz, C., Lisfeld, J., Meyer, K., Picelli, S., Pischimarov, J., Radlwimmer, B., Rausch, T., Rohde, M., Schilhabel, M., Scholtysik, R., Spang, R., Trautmann, H., Zenz, T., Borkhardt, A., Drexler, H. G., Moller, P., Macleod, R. A., Pott, C., Schreiber, S., Trumper, L., Loeffler, M., Stadler, P. F., Lichter, P., Eils, R., Kuppers, R., Hummel, M., Klapper, W., Rosenstiel, P., Rosenwald, A., Brors, B., and Siebert, R. (2012) Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet 44, 1316-1320.
Leich, E., Zamo, A., Horn, H., Haralambieva, E., Puppe, B., Gascoyne, R. D., Chan, W. C., Braziel, R. M., Rimsza, L. M., Weisenburger, D. D., Delabie, J., Jaffe, E. S., Fitzgibbon, J., Staudt, L. M., Mueller-Hermelink, H. K., Calaminici, M., Campo, E., Ott, G., Hernandez, L., and Rosenwald, A. (2011) MicroRNA profiles of t(14;18)-negative follicular lymphoma support a late germinal center B-cell phenotype. Blood 118, 5550-5558.
Hartmann, E. M., Campo, E., Wright, G., Lenz, G., Salaverria, I., Jares, P., Xiao, W., Braziel, R. M., Rimsza, L. M., Chan, W. C., Weisenburger, D. D., Delabie, J., Jaffe, E. S., Gascoyne, R. D., Dave, S. S., Mueller-Hermelink, H. K., Staudt, L. M., Ott, G., Bea, S., and Rosenwald, A. (2010) Pathway discovery in mantle cell lymphoma by integrated analysis of high resolution gene expression and copy number profiling. Blood 116, 953-961.
