New therapeutic strategies for reconstruction of bone defects with optimized RIA-derived autologous grafts and bone substitute materials - RIABONE

Sebastian Häusner, Bianca Schlierf, Theresa Kreuzahler, Marietta Herrmann

Collaborators: Torsten Blunk (Würzburg), Aleksandra Jaukovic, Dusko Spasovski, Petar S. Milosavljević  ( Belgrad), OSARTIS GmbH

Autologous bone transplantation is the current gold standard method for the treatment of long bone defects. Patient derived material for the procedure can either be harvested  directly from the iliac crest, or by Reamer-Irrigator-Aspirator® (RIA) technique when larger quantities of graft material are needed. The RIA technique produces two fractions, a solid phase which is usually used for the autograft transplant and a liquid phase that is typically cases not used for therapy. Recent studies indicate the high bone regenerative potential of RIA fractions, although the composition of cellular and soluble factors, particularly for the liquid fraction, remains unclear. Therefore one main aim of the „RIABONE“ project is the in-vitro analysis of the RIA fractions, in order to improve its regenerative potential and record pre-treatment strategies for surgical application from laboratory results. In combination with clinically approved bone substitute materials (PerOssal®), an interoperative protocol will be established to optimize currently available therapy options. The results of the in-vitro experiments will be put to test in subsequent „proof-of-concept“ preclinical and clinical trials.

This highly translational research project, with international collaboration from basic research, clinical and industry partners in Germany and Serbia is made possible by the Federal Ministry of Education and Research (BMBF).