Deutsch Intern
    Obelics

    Publications

    • Fernandez-Rebollo E, Eipel M, Seefried L, Hoffmann P, Strathmann K, Jakob F, Wagner W. Primary Osteoporosis Is Not Reflected by Disease-Specific DNA Methylation or Accelerated Epigenetic Age in Blood. J Bone Miner Res. 2018 Feb;33(2):356-361. doi: 10.1002/jbmr.3298. Epub 2017 Oct 23.
    • Fernandez-Rebollo E, Mentrup B, Ebert R, Franzen J, Abagnale G, Sieben T, Ostrowska A, Hoffmann P, Roux PF, Rath B, Goodhardt M, Lemaitre JM, Bischof O, Jakob F, Wagner W. Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells. Sci Rep. 2017 Jul 11;7(1):5132. doi: 10.1038/s41598-017-05207-1.

    • Vjetrovic J, Shankaranarayanan P, Mendoza-Parra MA, Gronemeyer H. Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. Aging Cell. 2014 Jun;13(3):487-96. doi: 10.1111/acel.12197. Epub 2014 Mar 4.
    • Schellenberg A, Mauen S, Koch CM, Jans R, de Waele P, Wagner W. Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes. BMC Res Notes. 2014 Apr 23;7:254. doi: 10.1186/1756-0500-7-254.
    • Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, Bauerschlag DO, Jöckel KH, Erbel R, Mühleisen TW, Zenke M, Brümmendorf TH, Wagner W. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol. 2014 Feb 3;15(2):R24. doi: 10.1186/gb-2014-15-2-r24.
    • Hemeda H, Giebel B, Wagner W. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Cytotherapy. 2014 Feb;16(2):170-80. doi: 10.1016/j.jcyt.2013.11.004.
    • Venables JP, Lapasset L, Gadea G, Fort P, Klinck R, Irimia M, Vignal E, Thibault P, Prinos P, Chabot B, Abou Elela S, Roux P, Lemaitre JM, Tazi J. MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nat Commun. 2013;4:2480. doi: 10.1038/ncomms3480.
    • Bonne-Andrea C, Kahli M, Mechali F, Lemaitre JM, Bossis G, Coux O. SUMO2/3 modification of cyclin E contributes to the control of replication origin firing. Nat Commun. 2013;4:1850. doi: 10.1038/ncomms2875. 
    • Kohler J, Popov C, Klotz B, Alberton P, Prall WC, Haasters F, Müller-Deubert S, Ebert R, Klein-Hitpass L, Jakob F, Schieker M, Docheva D. Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration. Aging Cell. 2013 Dec;12(6):988-99. doi: 10.1111/acel.12124. Epub 2013 Jul 22. 
    • Mendoza-Parra MA, Gronemeyer H. Genome-wide studies of nuclear receptors in cell fate decisions. Semin Cell Dev Biol. 2013 Dec;24(10-12):706-15. doi: 10.1016/j.semcdb.2013.07.001. Epub 2013 Aug 2. PubMed PMID: 23916718. 
    • Mendoza-Parra MA, Van Gool W, Mohamed Saleem MA, Ceschin DG, Gronemeyer H. A quality control system for profiles obtained by ChIP sequencing. Nucleic Acids Res. 2013 Nov;41(21):e196. doi: 10.1093/nar/gkt829. Epub 2013 Sep 14. 
    • Mendoza-Parra MA, Nowicka M, Van Gool W, Gronemeyer H. Characterising ChIP-seq binding patterns by model-based peak shape deconvolution. BMC Genomics. 2013 Nov 26;14:834. doi: 10.1186/1471-2164-14-834.
    • Hemeda H, Giebel B, Wagner W. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Cytotherapy. 2014 Feb;16(2):170-80. doi: 10.1016/j.jcyt.2013.11.004. 
    • Weidner CI, Walenda T, Lin Q, Wölfler MM, Denecke B, Costa IG, Zenke M, Wagner  W. Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture. Sci Rep. 2013 Nov 28;3:3372. doi: 10.1038/srep03372. 
    • Walenda G, Abnaof K, Joussen S, Meurer S, Smeets H, Rath B, Hoffmann K, Fröhlich H, Zenke M, Weiskirchen R, Wagner W. TGF-beta1 does not induce senescence of multipotent mesenchymal stromal cells and has similar effects in early and late passages. PLoS One. 2013 Oct 17;8(10):e77656. doi: 10.1371/journal.pone.0077656. eCollection 2013. 
    • Koch CM, Wagner W. Epigenetic biomarker to determine replicative senescence of cultured cells. Methods Mol Biol. 2013;1048:309-21. doi: 10.1007/978-1-62703-556-9_20. 
    • Hemeda H, Kalz J, Walenda G, Lohmann M, Wagner W. Heparin concentration is critical for cell culture with human platelet lysate. Cytotherapy. 2013 Sep;15(9):1174-81. doi: 10.1016/j.jcyt.2013.05.006. Epub 2013 Jul 9.
    • Willmann CA, Hemeda H, Pieper LA, Lenz M, Qin J, Joussen S, Sontag S, Wanek P, Denecke B, Schüler HM, Zenke M, Wagner W. To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture. PLoS One. 2013 May 29;8(5):e65324. doi: 10.1371/journal.pone.0065324. Print 2013.
    • Schellenberg A, Hemeda H, Wagner W. Tracking of replicative senescence in mesenchymal stem cells by colony-forming unit frequency. Methods Mol Biol. 2013;976:143-54. doi: 10.1007/978-1-62703-317-6_11.
    • Jost E, Lin Q, Weidner CI, Wilop S, Hoffmann M, Walenda T, Schemionek M, Herrmann O, Zenke M, Brümmendorf TH, Koschmieder S, Wagner W. Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia. Leukemia. 2014 Jun;28(6):1227-34. doi: 10.1038/leu.2013.362. Epub 2013 Nov 27.
    • Walenda G, Abnaof K, Joussen S, Meurer S, Smeets H, Rath B, Hoffmann K, Fröhlich H, Zenke M, Weiskirchen R, Wagner W. TGF-beta1 does not induce senescence of multipotent mesenchymal stromal cells and has similar effects in early and late passages. PLoS One. 2013 Oct 17;8(10):e77656. doi: 10.1371/journal.pone.0077656. eCollection 2013.
    • Weidner CI, Walenda T, Lin Q, Wölfler MM, Denecke B, Costa IG, Zenke M, Wagner W. Hematopoietic Stem and Progenitor Cells Acquire Distinct DNA-Hypermethylation  During in vitro Culture. Sci Rep. 2013 Nov 28;3:3372. doi: 10.1038/srep03372.
    • Mendoza-Parra MA, Nowicka M, Van Gool W, Gronemeyer H. Characterising ChIP-seq binding patterns by model-based peak shape deconvolution. BMC Genomics. 2013 Nov 26;14:834. doi: 10.1186/1471-2164-14-834.
    • Mendoza-Parra MA, Van Gool W, Mohamed Saleem MA, Ceschin DG, Gronemeyer H. A quality control system for profiles obtained by ChIP sequencing. Nucleic Acids Res. 2013 Nov;41(21):e196. doi: 10.1093/nar/gkt829. Epub 2013 Sep 14.
    • Ettou S, Humbrecht C, Benet B, Billot K, d'Allard D, Mariot V, Goodhardt M, Kosmider O, Mayeux P, Solary E, Fontenay M. Epigenetic control of NF-κB-dependent FAS gene transcription during progression of myelodysplastic syndromes. Mol Cancer Res. 2013 Jul;11(7):724-35. doi: 10.1158/1541-7786.MCR-12-0607. Epub 2013 Apr 19.
    • Bonne-Andrea C, Kahli M, Mechali F, Lemaitre JM, Bossis G, Coux O. SUMO2/3 modification of cyclin E contributes to the control of replication origin firing. Nat Commun. 2013;4:1850. doi: 10.1038/ncomms2875.
    • Venables JP, Lapasset L, Gadea G, Fort P, Klinck R, Irimia M, Vignal E, Thibault P, Prinos P, Chabot B, Abou Elela S, Roux P, Lemaitre JM, Tazi J. MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nat Commun. 2013;4:2480. doi: 10.1038/ncomms3480.
    • Neyret-Kahn H, Benhamed M, Ye T, Le Gras S, Cossec JC, Lapaquette P, Bischof O, Ouspenskaia M, Dasso M, Seeler J, Davidson I, Dejean A. Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation. Genome Res. 2013 Oct;23(10):1563-79. doi: 10.1101/gr.154872.113. Epub 2013 Jul 26.
    • Koch CM, Wagner W. Epigenetic biomarker to determine replicative senescence of cultured cells. Methods Mol Biol. 2013;1048:309-21. doi: 10.1007/978-1-62703-556-9_20.
    • Lin Q, Wagner W, Zenke M. Analysis of genome-wide DNA methylation profiles by BeadChip technology. Methods Mol Biol. 2013;1049:21-33. doi: 10.1007/978-1-62703-547-7_3.
    • Willmann CA, Hemeda H, Pieper LA, Lenz M, Qin J, Joussen S, Sontag S, Wanek P, Denecke B, Schüler HM, Zenke M, Wagner W. To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture. PLoS One. 2013 May 29;8(5):e65324. doi: 10.1371/journal.pone.0065324. Print 2013.
    • Schellenberg A, Hemeda H, Wagner W. Tracking of replicative senescence in mesenchymal stem cells by colony-forming unit frequency. Methods Mol Biol. 2013;976:143-54. doi: 10.1007/978-1-62703-317-6_11.
    • Kohler J, Popov C, Klotz B, Alberton P, Prall WC, Haasters F, Müller-Deubert S, Ebert R, Klein-Hitpass L, Jakob F, Schieker M, Docheva D. Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration. Aging Cell. 2013 Dec;12(6):988-99. doi: 10.1111/acel.12124. Epub 2013 Jul 22.
    • Steinert AF, Weissenberger M, Kunz M, Gilbert F, Ghivizzani SC, Göbel S, Jakob F, Nöth U, Rudert M. Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells. Arthritis Res Ther. 2012 Jul 20;14(4):R168. doi: 10.1186/ar3921.
    • Walsh JB, Lems WF, Karras D, Langdahl BL, Ljunggren O, Fahrleitner-Pammer A, Barrett A, Rajzbaum G, Jakob F, Marin F. Effectiveness of Teriparatide in women over 75 years of age with severe osteoporosis: 36-month results from the European Forsteo Observational Study (EFOS). Calcif Tissue Int. 2012 May;90(5):373-83.
      doi: 10.1007/s00223-012-9590-9. Epub 2012 Apr 1. 
    • Martin N, Benhamed M, Nacerddine K, Demarque MD, van Lohuizen M, Dejean A, Bischof O. Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 2012 Jan 4;31(1):95-109. doi: 10.1038/emboj.2011.370. Epub 2011 Oct 14.
    • Klotz B, Mentrup B, Regensburger M, Zeck S, Schneidereit J, Schupp N, Linden C, Merz C, Ebert R, Jakob F. 1,25-dihydroxyvitamin D3 treatment delays cellular aging in human mesenchymal stem cells while maintaining their multipotent capacity. PLoS One. 2012;7(1):e29959. doi: 10.1371/journal.pone.0029959. Epub 2012 Jan 5.
    • Benisch P, Schilling T, Klein-Hitpass L, Frey SP, Seefried L, Raaijmakers N, Krug M, Regensburger M, Zeck S, Schinke T, Amling M, Ebert R, Jakob F. The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One. 2012;7(9):e45142. doi: 10.1371/journal.pone.0045142. Epub 2012 Sep 24.
    • Wagner W. Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation? Stem Cell Res Ther. 2012 Dec 20;3(6):54. doi: 10.1186/scrt145.
    • Shankaranarayanan P, Mendoza-Parra MA, van Gool W, Trindade LM, Gronemeyer H. Single-tube linear DNA amplification for genome-wide studies using a few thousand cells. Nat Protoc. 2012 Jan 26;7(2):328-38. doi: 10.1038/nprot.2011.447.
    • Mendoza-Parra MA, Sankar M, Walia M, Gronemeyer H. POLYPHEMUS: R package for comparative analysis of RNA polymerase II ChIP-seq profiles by non-linear normalization. Nucleic Acids Res. 2012 Feb;40(4):e30. doi: 10.1093/nar/gkr1205. Epub 2011 Dec 7.
    • Besnard E, Babled A, Lapasset L, Milhavet O, Parrinello H, Dantec C, Marin JM, Lemaitre JM. Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs. Nat Struct Mol Biol. 2012 Aug;19(8):837-44. doi: 10.1038/nsmb.2339. Epub 2012 Jul 1.
    • Benhamed M, Herbig U, Ye T, Dejean A, Bischof O. Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells. Nat Cell Biol. 2012 Feb 26;14(3):266-75. doi: 10.1038/ncb2443.
    • Kramer J, Dazzi F, Dominici M, Schlenke P, Wagner W. Clinical perspectives of mesenchymal stem cells. Stem Cells Int. 2012;2012:684827. doi: 10.1155/2012/684827. Epub 2012 Dec 24.
    • Jakob F, Oertel H, Langdahl B, Ljunggren O, Barrett A, Karras D, Walsh JB, Fahrleitner-Pammer A, Rajzbaum G, Barker C, Lems WF, Marin F. Effects of teriparatide in postmenopausal women with osteoporosis pre-treated with bisphosphonates: 36-month results from the European Forsteo Observational Study. Eur J Endocrinol. 2012 Jan;166(1):87-97. doi: 10.1530/EJE-11-0740. Epub 2011 Nov 2. Erratum in: Eur J Endocrinol. 2012 Mar;166(3):563.
    • Steinert AF, Kunz M, Prager P, Barthel T, Jakob F, Nöth U, Murray MM, Evans CH, Porter RM. Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May;17(9-10):1375-88. doi: 10.1089/ten.TEA.2010.0413. Epub 2011 Mar 8.
    • Mendoza-Parra MA, Walia M, Sankar M, Gronemeyer H. Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics. Mol Syst Biol. 2011 Oct 11;7:538. doi: 10.1038/msb.2011.73.
    • Shankaranarayanan P, Mendoza-Parra MA, Walia M, Wang L, Li N, Trindade LM, Gronemeyer H. Single-tube linear DNA amplification (LinDA) for robust ChIP-seq. Nat Methods. 2011 Jun 5;8(7):565-7. doi: 10.1038/nmeth.1626.
    • Kuranda K, Vargaftig J, de la Rochere P, Dosquet C, Charron D, Bardin F, Tonnelle C, Bonnet D, Goodhardt M. Age-related changes in human hematopoietic stem/progenitor cells. Aging Cell. 2011 Jun;10(3):542-6. doi: 10.1111/j.1474-9726.2011.00675.x. Epub 2011 Mar 22.
    • Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Aït-Hamou N, Leschik J, Pellestor F, Ramirez JM, De Vos J, Lehmann S, Lemaitre JM. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 2011 Nov 1;25(21):2248-53. doi: 10.1101/gad.173922.111.
    • Prieur A, Besnard E, Babled A, Lemaitre JM. p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression. Nat Commun. 2011 Sep 13;2:473. doi: 10.1038/ncomms1473.
    • Martin N, Benhamed M, Nacerddine K, Demarque MD, van Lohuizen M, Dejean A, Bischof O. Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 2012 Jan 4;31(1):95-109. doi: 10.1038/emboj.2011.370. Epub 2011 Oct 14.
    • Limbert C, Päth G, Ebert R, Rothhammer V, Kassem M, Jakob F, Seufert J. PDX1-  and NGN3-mediated in vitro reprogramming of human bone marrow-derived mesenchymal stromal cells into pancreatic endocrine lineages. Cytotherapy. 2011 Aug;13(7):802-13. doi: 10.3109/14653249.2011.571248. Epub 2011 Apr 21.
    • Limbert C, Ebert R, Schilling T, Path G, Benisch P, Klein-Hitpass L, Seufert J, Jakob F. Functional signature of human islet-derived precursor cells compared  to bone marrow-derived mesenchymal stem cells. Stem Cells Dev. 2010 May;19(5):679-91. doi: 10.1089/scd.2009.0241.
    • Lescale C, Dias S, Maës J, Cumano A, Szabo P, Charron D, Weksler ME, Dosquet C, Vieira P, Goodhardt M. Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age. Aging Cell. 2010 Jun;9(3):410-9. doi: 10.1111/j.1474-9726.2010.00566.x. Epub 2010 Mar 13.
    • Guillemin C, Maleszewska M, Guais A, Maës J, Rouyez MC, Yacia A, Fichelson S, Goodhardt M, Francastel C. Chromatin modifications in hematopoietic multipotent and committed progenitors are independent of gene subnuclear positioning relative to repressive compartments. Stem Cells. 2009 Jan;27(1):108-15. doi: 10.1634/stemcells.2008-0755.
    • Kumar PP, Bischof O, Purbey PK, Notani D, Urlaub H, Dejean A, Galande S. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol. 2007 Jan;9(1):45-56. Epub 2006 Dec 17.
    • Carter S, Bischof O, Dejean A, Vousden KH. C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol. 2007 Apr;9(4):428-35. Epub 2007 Mar 18.
    • Bischof O, Schwamborn K, Martin N, Werner A, Sustmann C, Grosschedl R, Dejean A. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell. 2006 Jun 23;22(6):783-94. 
    • Kumar PP, Bischof O, Purbey PK, Notani D, Urlaub H, Dejean A, Galande S. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol. 2007 Jan;9(1):45-56. Epub 2006 Dec 17.

    • Jakob F, Ebert R, Ignatius A, Matsushita T, Watanabe Y, Groll J, Walles H. Bone tissue engineering in osteoporosis. Maturitas. 2013 Jun;75(2):118-24. doi: 10.1016/j.maturitas.2013.03.004. Epub 2013 Apr 4. Review.
    • Jakob F, Ebert R, Rudert M, Nöth U, Walles H, Docheva D, Schieker M, Meinel L, Groll J. In situ guided tissue regeneration in musculoskeletal diseases and aging : Implementing pathology into tailored tissue engineering strategies. Cell Tissue Res. 2012 Mar;347(3):725-35. doi: 10.1007/s00441-011-1237-z. Epub 2011 Oct 20. Review.
    • Álvarez R, Altucci L, Gronemeyer H, de Lera AR. Epigenetic multiple modulators. Curr Top Med Chem. 2011 Nov;11(22):2749-87. Review. PubMed PMID: 22039877.
    • Bischof O, Dejean A. SUMO is growing senescent. Cell Cycle. 2007 Mar 15;6(6):677-81. Epub 2007 Mar 20. Review.