Publications

• Eidmann, A., Geiger, F., Heinz, T., Jakuscheit, A., Docheva, D., Horas, K., Rudert, M., and Stratos, I. (2024). Our impact to global warming: a carbon footprinting analysis of orthopaedic operations. J Bone Joint Surg Am 106, 21, 1971-1977. doi:10.2106/JBJS.24.00212
  Article video summary:
  https://www.youtube.com/watch?v=ff34B25MbHY
• Evers, M., Stühmer, T., Schreder, M., Steinbrunn, T., Rudelius, M., Jundt, F., Ebert, R., Hartmann, T.N., Bargou, R.C., Rosenwald, A., and Leich, E. (2024). Association of ADAM family members with proliferation signaling and disease progression in multiple myeloma. Blood Cancer J 14, 1, 156. doi:10.1038/s41408-024-01133-4
• Graça, A., Kroner-Weigl, N., Reyes Alcaraz, V., Müller-Deubert, S., Rudert, M., and Docheva, D. (2024). Demonstration of self-assembled cell sheet culture and manual generation of a 3D tendon/ligament-like organoid using human dermal fibroblasts. J Vis Exp, 208. doi:10.3791/66047
  Article video summary:
  https://app.jove.com/v/201565/2d-expansion-2d-stimulation-and-3d-organoid-maturation-of-adult-normal-human-dermal-fibroblasts-for-tendon-research-and-engineering
• Grammens, J., Van Haver, A., Danckaers, F., Vuylsteke, K., Sijbers, J., Mahluf, L., Angele, P., Kon, E., Verdonk, P., and MEFISTO WP1 Group (including G. Pattappa and D. Docheva). (2024). Three-dimensional bone morphology is a risk factor for medial postmeniscectomy syndrome: A retrospective cohort study. J Exp Orthop 11, 3, e12090. doi:10.1002/jeo2.12090
• Harris, D., Groß, M., Staebler, S., Ebert, R., Seibel, J., and Boßerhoff, A.K. (2024). Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues. Cells 13, 22, 1831. doi:10.3390/cells13221831
• Herrmann, M., Schneidereit, J., Wiesner, S., Kuric, M., Rudert, M., Lüdemann, M., Srivastava, M., Schütze, N., Ebert, R., Docheva, D., and Jakob, F. (2024). Peripheral blood cells enriched by adhesion to CYR61 are heterogenous myeloid modulators of tissue regeneration with early endothelial progenitor characteristics. eCM Journal (European Cells & Materials), 48. doi:10.22203/eCM.v048a05
• Höppel, A., Bahr, O., Ebert, R., Wittmer, A., Seidenstuecker, M., Carolina Lanzino, M., Gbureck, U., and Dembski, S. (2024). Cu-doped calcium phosphate supraparticles for bone tissue regeneration. RSC Adv 14, 45, 32839-32851. doi:10.1039/d4ra04769a
• Ilic, J., Koelbl, C., Simon, F.T., Wussmann, M., Ebert, R., Trivanovic, D., and Herrmann, M. (2024). Liquid overlay and collagen-based 3D models for in vitro investigation of multiple myeloma. Tissue Eng Part C Methods. 30, 5, 193-205. doi:10.1089/ten.TEC.2023.0374
• Kovářík, T., Bělský, P., Křenek, T., Deshmukh, K., Forejtová, J., Medlín, R., Beneš, J., Svoboda, M., Kadlec, J., Pola, M., Jandová, V., Mikysek, P., Ilavský, J., Stich, T., Docheva, D., Strejcová, K., and Tišler, Z. (2024). Sol-gel derived silicate-phosphate glass SiO2–P2O5–CaO–TiO2: The effect of titanium isopropoxide on porosity and thermomechanical stability. Microporous and Mesoporous Materials 374, 113138. doi:10.1016/j.micromeso.2024.113138
• Křenek, T., Pola, J., Stich, T., Pattappa, G., Docheva, D., Koštejn, M., Medlín, R., Mikysek, P., Jandová, V., Pola, M., Kovářík, T., Cassel, J., Holzman, M., and Moskal, D. (2024). Hydrolytic instability of laser-ablatively deposited CaSi2 coatings in air and neutral water affects the behavior of bone healing-related cell types. Surf Interfaces 55. doi:10.1016/j.surfin.2024.105381
• Kuric, M., and Ebert, R. (2024). plotastic: Bridging Plotting and Statistics in Python. Journal of Open Source Software 9, 95, 6304. doi:10.21105/joss.06304
• Kuric, M., Beck, S., Schneider, D., Rindt, W., Evers, M., Meissner-Weigl, J., Zeck, S., Krug, M., Herrmann, M., Hartmann, T.N., Leich, E., Rudert, M., Docheva, D., Seckinger, A., Hose, D., Jundt, F., and Ebert, R. (2024). Modelling Myeloma Dissemination in vitro with hMSC-Interacting Subpopulations of INA-6 Cells and their Aggregation/Detachment Dynamics. Cancer Res Commun 4, 4, 1150-1164. doi:10.1158/2767-9764.CRC-23-0411
• Lenz, J.E., Pattappa, G., Voss, A., Zellner, J., Angele, P., and Docheva, D. (2024). Biofabrication Approaches to Tendon and Ligament Reconstruction. In: Espregueira-Mendes, J., Karlsson, J., Musahl, V. Ayeni, O.R. (eds.) Orthopaedic Sports Medicine, Cham: Springer International Publishing. doi:10.1007/978-3-030-65430-6_225-1
• Li, H., Luo, D., Xie, W., Ye, W., Chen, J., Alberton, P., Zhang, M., Feng, E., Docheva, D., and Lin, D. (2024). Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation. iScience 27, 11, 111042. doi:10.1016/j.isci.2024.111042
• Mut, J., Altmann, S., Reising, S., Meissner-Weigl, J., Driessen, M.D., Ebert, R., and Seibel, J. (2024). SiaNAl can be efficiently incorporated in glycoproteins of human mesenchymal stromal cells by metabolic glycoengineering. ACS Biomater Sci Eng 10, 1, 139-148. doi:10.1021/acsbiomaterials.2c01534
• Reyes Alcaraz, V., Pattappa, G., Miura, S., Angele, P., Blunk, T., Rudert, M., Hiraki, Y., Shukunami, C., and Docheva, D. (2024). A Narrative Review of the Roles of Chondromodulin-I (Cnmd) in Adult Cartilage Tissue. International Journal of Molecular Sciences 25, 11, 5839. doi:10.3390/ijms25115839
• Rindt, W.D., Krug, M., Yamada, S., Sennefelder, F., Belz, L., Cheng, W.H., Azeem, M., Kuric, M., Evers, M., Leich, E., Hartmann, T.N., Pereira, A.R., Hermann, M., Hansmann, J., Mussoni, C., Stahlhut, P., Ahmad, T., Yassin, M.A., Mustafa, K., Ebert, R., and Jundt, F. (2024). A 3D bioreactor model to study osteocyte differentiation and mechanobiology under perfusion and compressive mechanical loading. Acta Biomater 184, 210-225. doi:10.1016/j.actbio.2024.06.041
• Wagenbrenner, M., Heinz, T., Anderson, P.M., Stratos, I., Arnholdt, J., Mayer-Wagner, S., Horas, K., Docheva, D., Holzapfel, B.M., Rudert, M., and Weißenberger, M. (2024). Does Combined Treatment with Tranexamic Acid and Vancomycin Affect Human Chondrocytes In Vitro? Pharmaceuticals 17, 12. doi:10.3390/ph17121576
• Yambe, S., Yoshimoto, Y., Ikeda, K., Maki, K., Takimoto, A., Higuchi, S., Yu, X., Uchibe, K., Miura, S., Watanabe, H., Sakuma, T., Yamamoto, T., Tanimoto, K., Kondoh, G., Docheva, D., Adachi, T., and Shukunami, C. (2024). Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity. Front Cell Dev Biol 12, 1360041. doi:10.3389/fcell.2024.1360041. doi:10.3389/fcell.2024.1360041

• Evers, M., Schreder, M., Stuhmer, T., Jundt, F., Ebert, R., Hartmann, T.N., Altenbuchinger, M., Rudelius, M., Kuric, M., Rindt, W.D., Steinbrunn, T., Langer, C., Heredia-Guerrero, S.C., Einsele, H., Bargou, R.C., Rosenwald, A., and Leich, E. (2023). Prognostic value of extracellular matrix gene mutations and expression in multiple myeloma. Blood Cancer J 13, 1, 43. doi:10.1038/s41408-023-00817-7
• Graca, A.L., Gomez-Florit, M., Gomes, M.E., and Docheva, D. (2023). Tendon Aging. Subcell Biochem 103, 121-147. doi:10.1007/978-3-031-26576-1_7
• Horas, K., Abraham, M., Ebert, R., Weissenberger, M., Maier, G.S., Jakob, F., Rosenwald, A., and Rudert, M. (2023). Vitamin D Receptor Expression Is Significantly Decreased in Bone Metastases Compared to Matched Primary Breast Cancer Tumours. Cancer Invest 41, 2, 133-143. doi:10.1080/07357907.2022.2142604
• Kaltdorf, M., Breitenbach, T., Karl, S., Fuchs, M., Kessie, D.K., Psota, E., Prelog, M., Sarukhanyan, E., Ebert, R., Jakob, F., Dandekar, G., Naseem, M., Liang, C., and Dandekar, T. (2023). Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis. Sci Rep 13, 1, 1855. doi:10.1038/s41598-022-27098-7
• Kroner-Weigl, N., Chu, J., Rudert, M., Alt, V., Shukunami, C., and Docheva, D. (2023). Dexamethasone Is Not Sufficient to Facilitate Tenogenic Differentiation of Dermal Fibroblasts in a 3D Organoid Model. Biomedicines 11, 3. doi:10.3390/biomedicines11030772
• Maichl, D.S., Kirner, J.A., Beck, S., Cheng, W.H., Krug, M., Kuric, M., Ade, C.P., Bischler, T., Jakob, F., Hose, D., Seckinger, A., Ebert, R., and Jundt, F. (2023). Identification of NOTCH-driven matrisome-associated genes as prognostic indicators of multiple myeloma patient survival. Blood Cancer J 13, 1, 134. doi:10.1038/s41408-023-00907-6
• Pattappa, G., Markway, B.D., Docheva, D., and Johnstone, B. (2023). Physioxic Culture of Chondrogenic Cells. Methods Mol Biol 2598, 45-63. doi:10.1007/978-1-0716-2839-3_5
• Peshevska-Sekulovska, M., Gulinac, M., Rangelov, R., Docheva, D., Velikova, T., and Sekulovski, M. (2023). Navigating the Challenges of Gluten Enteropathy and Infertility: The Role of Celiac-Related Antibodies and Dietary Changes. Antibodies (Basel) 12, 4. doi:10.3390/antib12040079
• Riekert, M., Almanzar, G., Schmalzing, M., Schutze, N., Jakob, F., and Prelog, M. (2023). Mesenchymal stem cells modulate IL-17 and IL-9 production induced by Th17-inducing cytokine conditions in autoimmune arthritis: an explorative analysis. Adv Rheumatol 63, 1, 37. doi:10.1186/s42358-023-00317-z
• Ronca, A., D'Amora, U., Capuana, E., Zihlmann, C., Stiefel, N., Pattappa, G., Schewior, R., Docheva, D., Angele, P., and Ambrosio, L. (2023). Development of a highly concentrated collagen ink for the creation of a 3D printed meniscus. Heliyon 9, 12, e23107. doi:10.1016/j.heliyon.2023.e23107
• Sternstein, C.,* Böhm, T.M.,* Fink, J., Meyr, J., Ludemann, M., Krug, M., Kriukov, K., Gurdap, C.O., Sezgin, E., Ebert, R.,* and Seibel, J.* (2023a). Correction to Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells. Bioconjug Chem 34, 10, 1923. doi:10.1021/acs.bioconjchem.3c00392
• Sternstein, C.,* Böhm, T.M.,* Fink, J., Meyr, J., Ludemann, M., Krug, M., Kriukov, K., Gurdap, C.O., Sezgin, E., Ebert, R.,* and Seibel, J.* (2023b). Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells. Bioconjug Chem 34, 7, 1221-1233. doi:10.1021/acs.bioconjchem.3c00091
• Watzling, M., Klaus, L., Weidemeier, T., Horder, H., Ebert, R., Blunk, T., and Bauer-Kreisel, P. (2023). Three-Dimensional Breast Cancer Model to Investigate CCL5/CCR1 Expression Mediated by Direct Contact between Breast Cancer Cells and Adipose-Derived Stromal Cells or Adipocytes. Cancers 15, 13, 3501. doi:10.3390/cancers15133501
• Zhang, J., Frank, C., Byers, P., Djordjevic, S., Docheva, D., Clausen-Schaumann, H., Sudhop, S., and Huber, H.P. (2023). Dynamics of single cell femtosecond laser printing. Biomed Opt Express 14, 5, 2276-2292. doi:10.1364/BOE.480286

       *: equal contribution

• Alagboso, F.I., Mannala, G.K., Walter, N., Docheva, D., Brochhausen, C., Alt, V., and Rupp, M. (2022). Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection. Bone Joint Res 11, 5, 327-341. doi:10.1302/2046-3758.115.BJR-2021-0395.R1
• Angele, P., Docheva, D., Pattappa, G., and Zellner, J. (2022a). Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach. Knee Surg Sports Traumatol Arthrosc 30, 4, 1138-1150. doi:10.1007/s00167-021-06497-9
• Angele, P., Docheva, D., Pattappa, G., and Zellner, J. (2022b). Correction to: Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach. Knee Surg Sports Traumatol Arthrosc 30, 4, 1151. doi:10.1007/s00167-021-06622-8
• Brandl, A., Solimando, A.G., Mokhtari, Z., Tabares, P., Medler, J., Manz, H., Da Via, M.C., Croci, G.A., Kurzwart, M., Thusek, S., Schneider, T., Ebert, R., Jakob, F., Einsele, H., and Beilhack, A. (2022). Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans. Blood Adv 6, 7, 2195-2206. doi:10.1182/bloodadvances.2021004354
• Calejo, I., Labrador-Rached, C.J., Gomez-Florit, M., Docheva, D., Reis, R.L., Domingues, R.M.A., and Gomes, M.E. (2022). Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology. Adv Healthc Mater 11, 15, e2102863. doi:10.1002/adhm.202102863
• Ebert, R.*, Weissenberger, M.*, Braun, C., Wagenbrenner, M., Herrmann, M., Müller-Deubert, S., Krug, M., Jakob, F., and Rudert, M. (2022). Impaired regenerative capacity and senescence-associated secretory phenotype in mesenchymal stromal cells from samples of patients with aseptic joint arthroplasty loosening. J Orthop Res 40, 2, 513-523. doi:10.1002/jor.25041
• Krenek, T., Stich, T., Docheva, D., Mikysek, P., Kostejn, M., Jandova, V., Fajgar, R., Pola, M., Kovarik, T., Moskal, D., Forejtova, J., and Pola, J. (2022). Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium. Surf Coat Tech 447. doi:10.1016/j.surfcoat.2022.128820
• Mannala, G.K., Rupp, M., Walter, N., Brunotte, M., Alagboso, F., Docheva, D., Brochhausen, C., and Alt, V. (2022). Microbiological and ultrastructural evaluation of bacteriophage 191219 against planktonic, intracellular and biofilm infection with Staphylococcus aureus. Eur Cell Mater 43, 66-78. doi:10.22203/eCM.v043a07
• Riedl, M., Rupp, M., Walter, N., Henssler, L., Kerschbaum, M., Popp, D., Vadala, G., Alt, V., Docheva, D., and Pfeifer, C.G. (2022). Practical Relevance of Institutional Guidelines in Translational Large Animal Studies of Cartilage Repair-A Multidisciplinary Survey. Medicina (Kaunas) 58, 12. doi:10.3390/medicina58121834
• Schulze-Tanzil, G.G., Delgado-Calcares, M., Stange, R., Wildemann, B., and Docheva, D. (2022). Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon. Bone Joint Res 11, 8, 561-574. doi:10.1302/2046-3758.118.BJR-2021-0576.R1
• Seiler, J., Ebert, R., Rudert, M., Herrmann, M., Leich, E., Weissenberger, M., and Horas, K. (2022). Bone Metastases of Diverse Primary Origin Frequently Express the VDR (Vitamin D Receptor) and CYP24A1. J Clin Med 11, 21. doi:10.3390/jcm11216537
• Stich, T., Alagboso, F., Krenek, T., Kovarik, T., Alt, V., and Docheva, D. (2022). Implant-bone-interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo. Bioeng Transl Med 7, 1, e10239. doi:10.1002/btm2.10239
• Wagenbrenner, M., Poker, K., Heinz, T., Herrmann, M., Horas, K., Ebert, R., Mayer-Wagner, S., Holzapfel, B.M., Rudert, M., Steinert, A.F., and Weißenberger, M. (2022). Mesenchymal Stromal Cells (MSCs) Isolated from Various Tissues of the Human Arthritic Knee Joint Possess Similar Multipotent Differentiation Potential. Applied Sciences 12, 4, 2239.
• Walter, N., Stich, T., Docheva, D., Alt, V., and Rupp, M. (2022). Evolution of implants and advancements for osseointegration: A narrative review. Injury 53 Suppl 3, S69-S73. doi:10.1016/j.injury.2022.05.057
• Wang, G., Alagboso, F.I., Walter, N., Baertl, S., Brochhausen, C., Docheva, D., Rupp, M., and Alt, V. (2022). Bone regeneration after marginal bone resection in two-stage treatment of chronic long bone infection - a combined histopathological and clinical pilot study. Injury 53, 10, 3446-3457. doi:10.1016/j.injury.2022.07.008

• Altmann, S., Mut, J., Wolf, N., Meissner-Weigl, J., Rudert, M., Jakob, F., Gutmann, M., Luhmann, T., Seibel, J., and Ebert, R. (2021). Metabolic Glycoengineering in hMSC-TERT as a Model for Skeletal Precursors by Using Modified Azide/Alkyne Monosaccharides. Int J Mol Sci 22, 6, 2820. doi:10.3390/ijms22062820
• Chu, J., Pieles, O., Pfeifer, C.G., Alt, V., Morsczeck, C., and Docheva, D. (2021). Dental follicle cell differentiation towards periodontal ligament-like tissue in a self-assembly three-dimensional organoid model. Eur Cell Mater 42, 20-33. doi:10.22203/eCM.v042a02
• Delgado Caceres, M., Angerpointner, K., Galler, M., Lin, D., Michel, P.A., Brochhausen, C., Lu, X., Varadarajan, A.R., Warfsmann, J., Stange, R., Alt, V., Pfeifer, C.G., and Docheva, D. (2021). Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon. Cell Death Dis 12, 11, 1049. doi:10.1038/s41419-021-04298-z
• Di Pauli von Treuheim, T., Torre, O.M., Ferreri, E.D., Nasser, P., Abbondandolo, A., Delgado Caceres, M., Lin, D., Docheva, D., and Iatridis, J.C. (2021). Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration. Cartilage 13, 2_suppl, 604S-614S. doi:10.1177/19476035211029696
• Frey, S.P., Yorumazel, B., Holscher-Doht, S., Eden, L., Schütze, N., Meffert, R.H., and Jansen, H. (2021). CYR61 improves muscle force recreation in a rabbit trauma model. Technol Health Care 29, 6, 1129-1140. doi:10.3233/THC-191635
• Křenek, T., Jandova, V., Kovářík, T., Pola, M., Moskal, D., Pola, J., Stich, T., Docheva, D., Fajgar, R., Mikysek, P., and Kolska, Z. (2021). Micro/nano-structured titanium surfaces modified by NaOH-CaCl2-heat-water treatment: Biomimetic calcium phosphate deposition and hMSCs behavior. Mater Chem Phys 272. doi:10.1016/j.matchemphys.2021.124896
• Křenek, T., Kovářík, T., Pola, J., Stich, T., and Docheva, D. (2021). Nano and micro-forms of calcium titanate: Synthesis, properties and application. Open Ceramics 8, 100177. doi:10.1016/j.oceram.2021.100177
• Křenek, T., Pola, J., Docheva, D., Stich, T., Fajgar, R., Kovářík, T., Pola, M., Martan, J., Moskal, D., Jandova, V., Kupcik, J., and Mikysek, P. (2021). Porous micro/nano structured oxidic titanium surface decorated with silicon monoxide. Surf Interfaces 26. doi:10.1016/j.surfin.2021.101304
• Madry, H., Grassel, S., Noth, U., Relja, B., Bernstein, A., Docheva, D., Kauther, M.D., Katthagen, J.C., Bader, R., van Griensven, M., Wirtz, D.C., Raschke, M.J., and Huber-Lang, M. (2021). The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus? Eur J Med Res 26, 1, 56. doi:10.1186/s40001-021-00521-x
• Pattappa, G., Reischl, F., Jahns, J., Schewior, R., Lang, S., Zellner, J., Johnstone, B., Docheva, D., and Angele, P. (2021). Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia. Front Bioeng Biotechnol 9, 789621. doi:10.3389/fbioe.2021.789621
• Shirley, A.J., Schweeberg, S., Waag, T., Peindl, M., Dandekar, G., Walles, H., Jakob, F., Krueger, A., and Ebert, R. (2021). The influence of differently functionalized nanodiamonds on proliferation, apoptosis and EMT/MET phenomena in 2D and 3D tumor cell cultures. J Mater Chem B 9, 45, 9395-9405. doi:10.1039/d1tb01739j
• Xu, Y., Yin, H., Chu, J., Eglin, D., Serra, T., and Docheva, D. (2021). An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells. Biomater Sci 9, 4, 1237-1245. doi:10.1039/d0bm01127d
• Yin, H., Strunz, F., Yan, Z., Lu, J., Brochhausen, C., Kiderlen, S., Clausen-Schaumann, H., Wang, X., Gomes, M.E., Alt, V., and Docheva, D. (2021). Corrigendum to "Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells" [Biomaterials 236 (2020) 119,802]. Biomaterials 269, 120617. doi:10.1016/j.biomaterials.2020.120617
• Zhang, J., Byers, P., Erben, A., Frank, C., Schulte-Spechtel, L., Heymann, M., Docheva, D., Huber, H.P., Sudhop, S., and Clausen-Schaumann, H. (2021a). Single Cell Bioprinting with Ultrashort Laser Pulses. Adv Funct Mater 31, 19. doi:10.1002/adfm.202100066
• Zhang, J., Geiger, Y., Sotier, F., Djordjevic, S., Docheva, D., Sudhop, S., Clausen-Schaumann, H., and Huber, H.P. (2021b). Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations. Micromachines (Basel) 12, 10. doi:10.3390/mi12101172