Prof. Dr. Antje Gohla

Institute: Institute for Pharmacology and Toxicology

Abstract: Targeting the intrinsic metabolism of immune or tumor cells is a therapeutic strategy in autoimmunity, chronic inflammation or cancer. Metabolite repair enzymes may represent an alternative target class for selective metabolic inhibition, but pharmacological tools to test this concept are needed. I will present our recent identification of small molecule inhibitors that target a prototypical metabolite repair enzyme in glycolysis, and discuss ongoing projects and emerging biomedical implications.