Latrophilin signalling in tissue polarity and morphogenesis. In Adhesion-GPCRs: Structure to Function
01.01.2010
Langenhan T, Russ AP (2010)
Springer, Yona S., Stacey M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706:37-48
Understanding the mechanisms that coordinate the polarity of cells and tissues during embryogenesis and morphogenesis is a fundamental problem in developmental biology. We have recently demonstrated that the putative neurotoxin receptor lat-1 defines a mechanism required for the alignment of cell division planes in the early embryo of the nematode C. elegans. Our analysis suggests that lat-1 is required for the propagation rather than the initial establishment of polarity signals. Similar to the role of the flamingo/CELSR protein family in the control of planar cell polarity, these results implicate an evolutionary conserved subfamily of adhesion-GPCRs in the control of tissue polarity and morphogenesis.
